/* Global Styles  */

@import url('https://fonts.googleapis.com/css2?family=Noto+Sans:ital,wdth,wght@0,62.5..100,100..900;1,62.5..100,100..900&family=Roboto+Condensed:ital,wght@0,100..900;1,100..900&display=swap');

a:focus,
button:focus {
	outline: auto;
	outline-color: blue;
}

.desktop-only {
	display: block;
}

.mobile-only {
	display: none;
}

.nowrap-space {
	white-space: nowrap;
}

sup {
	top: -.5em;
}

sub,
sup {
	font-size: 75%;
	line-height: 0;
	position: relative;
	vertical-align: baseline;
}

#recurrencen-mibc {
	background: #F8F8F8;
}

.cmp-experiencefragment--header {
	background: url(/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/desktop/body-bg.jpeg);
	background-repeat: no-repeat;
	background-size: cover;
	padding: 27px 0 0 0;
}

.cmp-text {
	padding: 0 !important;
}

#header-wrap {
	width: 100%;
	max-width: 1238px;
	margin: 0 auto;
    position: relative;
}

#header-wrapper {
	background: rgba(255, 255, 255, 0.50);
	height: 55px;
	backdrop-filter: blur(12px);
	align-items: center;
	position: fixed;
	top: 27px;
	padding: 0;
	z-index: 1000;
	width: 100%;
}

#header-wrapper .cmp-text {
	padding: 0;
}

.header-wrap {
	display: flex;
	justify-content: space-between;
}

#sec-nav {
	position: relative;
	display: inline-flex;
	top: -43px;
	float: right;
}

#sec-nav .cmp-navigation__group {
	flex-wrap: nowrap;
	gap: 50px;
}

#sec-nav li.cmp-navigation__item {
	padding: 0;
	margin: 0;
}

#sec-nav li.cmp-navigation__item a.cmp-navigation__item-link {
	color: #1A281A;
	font-family: "Roboto Condensed";
	font-size: 16px;
	font-style: normal;
	font-weight: 500;
	line-height: 55px;
	display: inline-block;
}

#sec-nav li.cmp-navigation__item a.cmp-navigation__item-link:hover,
#sec-nav li.cmp-navigation__item a.cmp-navigation__item-link.active {
	text-decoration: underline;
	text-decoration-color: #F0AB00;
	text-decoration-thickness: 3px;
}

img.privacy--icon {
    width: 30px; 
    margin-left: 3px; 
    position:relative; 
    top: 2px;
}

.logo-wrapper a {
	display: block;
	padding: 11px 0 0 0;
}


#banner-wrap .cmp-text {
	padding: 0;
}

#container-I {
	background-image: url('/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/desktop/body-bg-new.jpg');
	background-repeat: no-repeat;
	background-size: cover;
	background-position: left top -18px;
}

.tree-bg-wrap {
    content: '';
    position: absolute;
    left: 0;
    bottom: 130px;
    height: 1071px;
    width: 100%;
    background-image: url(/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/desktop/body-bg-2-l-tree.png), url(/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/desktop/body-bg-2-r-tree.png);
    background-position: right bottom 20px, left bottom 20px;
    background-repeat: repeat-x, no-repeat;
    background-size: contain;
}

#container-I-wrap {
	/*width: 100%;
    max-width: 1254px;
    margin: 0 auto;
    padding: 221px 0 134px 0;*/
	padding: 221px 0 203px 0;
}

#banner-wrap {
	display: flex;
	justify-content: flex-end;
	position: relative;
	width: 100%;
	max-width: 1254px;
	margin: 0 auto;
}

#banner-wrap:before {
	content: 'FPO';
	position: absolute;
	color: rgba(255, 0, 255, 0.28);
	font-family: "Roboto Condensed";
	font-size: 70px;
	font-style: normal;
	font-weight: 700;
	line-height: 70px;
	/* 100% */
	transform: rotate(-45.342deg);
	left: 270px;
	top: 140px;
	display: none;
}

.banner-wrapper {
	width: 647px;
}

.yellow-bar {
	width: 637px;
	height: 64px;
	background: #F0AB00;
	color: #262626;
	font-family: "Noto Sans";
	font-size: 19px;
	font-style: normal;
	font-weight: 500;
	line-height: 24px;
	/* 126.316% */
	letter-spacing: 0.57px;
	padding: 8px 25px 0 15px;
	margin: 0 0 0 5px;
}

.banner-wrapper h1 {
	color: #FFF;
	text-shadow: 2px 2px 20px #000;
	font-family: "Noto Sans";
	font-size: 100px;
	font-style: normal;
	font-weight: 600;
	line-height: 100px;
	/* 100% */
	text-transform: uppercase;
	margin: 22px 0 0 0;
	position: relative;
}

.banner-wrapper h1 span {
	color: #FFF;
	text-shadow: 2px 2px 20px #000;
	font-family: "Noto Sans";
	font-size: 41px;
	font-style: normal;
	font-weight: 500;
	line-height: 45px;
	letter-spacing: 0.82px;
	text-transform: uppercase;
	word-spacing: 0.01em;
	position: absolute;
	left: 0;
	bottom: -60px;
}

#white-box-bg {
	position: relative;
}

#white-box {
	width: 100%;
	max-width: 1240px;
	margin: 138px auto 0 auto;
	height: 740px;
	/*background: rgba(255, 255, 255, 0.95);*/
	background: rgba(255, 255, 255, 0.85);
	backdrop-filter: blur(12px);
	padding: 62px 0 0 0;
	position: relative;
}

#is-bcg-alone-enough {
	font-size: 0px;
	position: absolute;
	top: -80px;
}

.h2 {
	color: #1A281A;
	text-align: center;
	font-family: "Roboto Condensed";
	font-size: 52px;
	font-style: normal;
	font-weight: 700;
	line-height: 40px;
	/* 67.308% */
	text-transform: uppercase;
	background-image: url('/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/desktop/gold-line.png'),
		url('/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/desktop/gold-line.png');
	margin: 0 59px 29px 59px;
	background-repeat: no-repeat;
	background-position: left center, right center;
	background-size: 25% 4px;
}

.h2 span {
	/*padding: 0 24px;
    background: #f0f5f7; */
}

p.p1 {
	/* max-width: 790px; */
	max-width: 850px;
	color: #262626;
	text-align: center;
	font-family: 'Roboto Condensed';
	font-size: 28px;
	font-style: normal;
	font-weight: 500;
	line-height: 36px;
	/* 130.769% */
	margin: 0 auto;
}

.h3 {
	color: #172517;
	text-align: center;
	font-family: 'Roboto Condensed';
	font-size: 28px;
	font-style: normal;
	font-weight: 400;
	line-height: 36px;
	/* 128.571% */
	letter-spacing: 0.28px;
	margin: 32px 0 36px 0;
	padding: 0 200px;
}

.h3 span {
	color: #172517;
	font-weight: 900;
	font-family: 'Roboto Condensed';
	text-transform: uppercase;
}

.factors-graphics {
	text-align: center;
	display: none;
}

.factors-graphics img {
	margin: 0 auto;
    padding: 0 0 0 74px;
}

.factors-img-wrap {
    position: absolute;
    width: 100%;
    height: 296px;
    text-align: center;
    top: 309px;
    display: flex;
    justify-content: center;
}

.factors-img-wrap img {
    padding: 0 0 0 73px;
}

.rect-wrap {
	max-width: 928px;
	width: 100%;
	/*height: 364px;*/
	background: rgba(23, 37, 23, 0.90);
	box-shadow: 4px 4px 10px 0 rgba(0, 0, 0, 0.50);
	backdrop-filter: blur(12px);
	margin: -82px auto -368px auto;
	display: flex;
	padding: 40px 0;
	gap: 41px;
	justify-content: center;
	position: relative;
	z-index: 1;
}

.rect-wrap .rect-left,
.rect-wrap .rect-right {
	background: #E7ECEF;
	width: 348px;
	/*height: 283px;*/
	text-align: left;
	padding: 37px 0 23px 34px;
}

.rect-wrap .row-1 {
	display: flex;
	gap: 10px;
}

.rect-wrap .row-1 span {
	color: #1A281A;
	text-align: center;
	font-family: "Roboto Condensed";
	font-size: 66px;
	font-style: normal;
	font-weight: 900;
	line-height: 66px;
	letter-spacing: -1.317px;
	position: relative;
}


.rect-wrap .row-1 span:before {
	content: 'APPROX.';
	color: #1A281A;
	text-align: center;
	font-family: "Roboto Condensed";
	font-size: 10px;
	font-style: normal;
	font-weight: 700;
	line-height: 10px;
	position: absolute;
	top: -5px;
	letter-spacing: 0;
}

.rect-wrap .title-1 {
	color: #1A281A;
	font-family: "Roboto Condensed";
	font-size: 17px;
	font-style: normal;
	font-weight: 500;
	line-height: 21px;
	text-transform: uppercase;
	margin: 0 0 15px 0;
}

.rect-wrap .title-1 span {
	color: #1A281A;
	font-family: "Roboto Condensed";
	font-size: 17px;
	font-style: normal;
	font-weight: 900;
	line-height: 21px;
	text-transform: uppercase;
	display: inline-block;
}

.rect-wrap .para-type-1 {
	color: #1A281A;
	font-family: "Noto Sans";
	font-size: 16px;
	font-style: normal;
	font-weight: 400;
	line-height: 20px;
	padding: 0 50px 0 0;
}

.rect-wrap .para-footnotes {
	color: #1A281A;
	font-family: "Noto Sans";
	font-size: 13px;
	font-style: normal;
	font-weight: 400;
	line-height: 16px;
	margin: 8px 0 0 0;
	text-indent: -8px;
    padding: 0 10px 0 0;
}

.rect-wrap .rect-right .para-footnotes,
.rect-wrap .rect-right .para-type-1,
.rect-wrap .rect-right .title-1 span,
.rect-wrap .rect-right .title-1,
.rect-wrap .rect-right .row-1 span,
.rect-wrap .rect-right .row-1 span:before {
	color: #550035;
}

.rect-wrap .rect-right .para-footnotes {
	margin: 24px 0 0 0;
}

#after-bcg-fails {
	padding: 86px 0 0 0;
	background: #F8F8F8;
	position: relative;
	margin: 168px 0 0 0;
}

#after-bcg-wrap {
	max-width: 1119px;
	margin: 0 auto;
	width: 100%;
}

#if-bcg-fails {
    position: absolute;
    font-size: 0;
    top: -120px;
    left: 0;
    display: inline-block;
    width: 100%;
}

.after-bcg-fails .h2 {
	background-size: 11.2% 4px;
	margin: 0 0 37px 0;
}

.after-bcg-fails .p1 {
	margin: 0 0 23px 33px;
	text-align: left;
}

.recommend-box {
	max-width: 1119px;
	width: 100%;
	background: rgba(239, 239, 239, 0.90);
	filter: drop-shadow(4px 4px 10px rgba(0, 0, 0, 0.50));
	/*backdrop-filter: blur(12px);*/
	padding: 32px 0;
	margin: 0 0 21px 0;
}

.recommend-box .recommend-title {
	color: #262626;
	text-align: center;
	font-family: "Roboto Condensed";
	font-size: 28px;
	font-style: normal;
	font-weight: 700;
	line-height: 30px;
	/* 71.429% */
	letter-spacing: 0.28px;
	text-transform: uppercase;
	margin: 0 0 32px 0;
}

.recommend-flex {
	display: flex;
	gap: 55px;
	justify-content: center;
	align-items: center;
}

.recommend-flex>div {
	display: flex;
	justify-content: center;
	align-items: center;
	gap: 15px;
}

.recommend-flex>div span {
	color: #550035;
	font-family: "Roboto Condensed";
	font-size: 32px;
	font-style: normal;
	font-weight: 700;
	line-height: 34px;
	/* 106.25% */
	letter-spacing: 0.32px;
}

.recommend-flex .cystectomy span {
	color: #1A281A;
}

.recommend-flex .vs-text {
	color: #454545;
	font-family: "Roboto Condensed";
	font-size: 18px;
	font-style: normal;
	font-weight: 700;
	line-height: 21px;
	/* 116.667% */
	text-transform: uppercase;
}

.after-bcg-fails .p2 {
	color: #262626;
	font-family: "Noto Sans";
	font-size: 16px;
	font-style: normal;
	font-weight: 400;
	line-height: 22px;
	padding: 0 0 0 33px;
	margin: 0 0 48px 0;
}

.after-bcg-fails .h3 {
	color: #262626;
	font-family: "Roboto Condensed";
	font-size: 28px;
	font-style: normal;
	font-weight: 500;
	line-height: normal;
	text-align: left;
	padding: 0;
	margin: 0 0 10px 33px
}


.after-bcg-fails .h3 span {
	color: #172517;
	font-weight: 900;
	font-family: "Roboto Condensed";
	text-transform: none;
}

.after-bcg-fails .p3 {
	color: #262626;
	font-family: "Roboto Condensed";
	/* font-size: 16px; */
	font-size: 26px;
	font-style: normal;
	font-weight: 400;
	/* line-height: 27px; */
	line-height: 34px;
	/* 168.75% */
	letter-spacing: 0.16px;
	/* margin: 0 0 37px 0; */
	margin: 0 0 37px 33px;
}

.after-bcg-fails .p3 span {
	font-size: 24px;
	font-style: normal;
	font-weight: 900;
	line-height: 27px;
	letter-spacing: 0.24px;
	text-transform: uppercase;
}

.box-3-col {
	display: flex;
	gap: 40px;
	padding: 0;
	justify-content: center;
}

.box-3-col>div {
	background: rgba(238, 238, 238, 0.90);
	box-shadow: 4px 4px 10px 0 rgba(0, 0, 0, 0.50);
	/*backdrop-filter: blur(12px);*/
	padding: 24px 14px 24px 35px;
	display: flex;
	gap: 8px;
	justify-content: flex-start;
	z-index: 1;
	max-width: 325px;
	align-items: center;
}

.box-3-col .effects {
	padding: 24px 14px 24px 35px;
}

.box-3-col .emotional {
	padding: 24px 14px 24px 22px;
}

.box-3-col .function {
	padding: 24px 14px 24px 14px;
}

.box-3-col>div span {
	color: #550035;
	font-family: "Roboto Condensed";
	font-size: 26px;
	font-style: normal;
	font-weight: 700;
	line-height: normal;
}

.box-3-col>div img {
	width: 76.119px;
	height: 80.727px;
	flex-shrink: 0;
}

#local-systemic-therapies {
	/* background-image: url(/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/desktop/bottom-bg.png); */
	background-image: url(/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/desktop/bottom-bg-blue.png);
	background-repeat: repeat-x;
	position: relative;
	background-position: left bottom;
	padding: 110px 0 0 0;
    background-size: contain;
}
#local-systemic-therapies:after {
	content: '';
	position: absolute;
	left: 0px;
	bottom: 0px;
	height: 1011px;
    width: 558px;
    background-image: url(/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/desktop/bottom-bg-left-new.png);
    background-size: 51%;
	background-repeat: no-repeat;
    background-position: left bottom;
}
#local-systemic-therapies:before {
    right: 0;
    content: '';
    position: absolute;
    left: auto;
    bottom: 0px;
    height: 867px;
    width: 572px;
    background-image: url(/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/desktop/bottom-bg-right.png);
    background-repeat: no-repeat;
    z-index: 1;
    background-size: 51%;
    background-position: right bottom;
}
#local-therapies .p1 {
	margin: 0 0 38px 0;
	text-align: left;
	max-width: 100%;
	padding: 0 34px;
}

#local-therapies {
	max-width: 1110px;
	margin: 0 auto;
	width: 100%;
}

.local-systemic-therapies .h2 {
	margin: 0 0 39px 0;
	background-size: 18% 4px;
	color: #172517;
}

.yellow-box {
	background: #F0AB00;
	box-shadow: 4px 4px 10px 0 rgba(0, 0, 0, 0.50);
	backdrop-filter: blur(12px);
	display: flex;
	align-items: center;
	max-width: 1119px;
	height: 203px;
	width: 100%;
	position: relative;
	padding: 0 69px 0 60px;
	justify-content: space-between;
}

.yellow-box-text {
	color: #262626;
	font-family: "Roboto Condensed";
	font-size: 28px;
	font-style: normal;
	font-weight: 500;
	line-height: 38px;
	/* 135.714% */
	letter-spacing: 0.28px;
	width: 701px;
}

.yellow-box-text span {
	color: #262626;
	font-family: "Roboto Condensed";
	font-size: 28px;
	font-style: normal;
	font-weight: 900;
	line-height: 38px;
	letter-spacing: 0.28px;
}

.yellow-box .systemic-local-icon {
	position: relative;
	top: 5px;
}

.local-systemic-therapies {
	padding: 0 0 168px 0;
}


#footer-wrapper {
	background: #550035;
	color: #FFF;
	padding: 29px 0 71px 0;
}

.footer-reference-sec {
	border-bottom: 4px solid #F0AB00;
	margin: 0 0 57px 0;
	padding: 0 0 25px 0;
}

#footer-notes-wrap {
	margin: 0 auto;
	width: 100%;
	max-width: 1121px;
}

.footer-reference-sec p {
	color: #FFF;
	font-family: "Noto Sans";
	font-size: 14px;
	font-style: normal;
	font-weight: 400;
	line-height: 16px;
	/* 114.286% */
	letter-spacing: 0.14px;
}

.footer-reference-sec p a {
	/*word-break: break-all;*/
    overflow-wrap: break-word;
    word-wrap: break-word;
    word-break: break-word;
}

.footer-reference-sec p b {
	font-weight: 700;
}

.footer-reference-sec p.abbreviation {
	margin: 0 0 11px 0;
}

#footer-nav-wrap {
	margin: 0 auto;
	width: 100%;
	max-width: 1121px;
}

.footer-nav-sec {
	color: #FFF;
	text-align: center;
	font-family: "Noto Sans";
	font-size: 13px;
	font-style: normal;
	font-weight: 400;
	line-height: 17px;
	/* 130.769% */
}

#footer-nav-wrap .footer-nav-sec ul {
	display: flex;
	gap: 20px;
	justify-content: center;
	max-width: 720px;
	flex-wrap: wrap;
	margin: 0 auto 30px auto;
}

.footer-nav-sec ul li a {
	color: #FFF;
	font-family: "Noto Sans";
	font-size: 16px;
	font-style: normal;
	font-weight: 400;
	line-height: normal;
	text-decoration-line: underline;
}

.footer-nav-sec .copyright-desc span {
	display: block;
}

.footer-nav-sec .copyright-desc {
	padding: 17px 0 22px 0;
}

#after-bcg-fails:before {
	content: '';
	position: absolute;
	right: 0;
	top: 110px;
	height: 309px;
	width: 379px;
	background-image: url(/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/desktop/crack-right.png);
	z-index: 0;
	background-position: right top -29px;
	background-repeat: no-repeat;
	background-size: 100%;
}

#after-bcg-fails:after {
	content: '';
	position: absolute;
	left: 0;
	bottom: 13px;
	height: 374px;
	width: 268px;
	background-image: url(/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/desktop/crack-left.png);
	z-index: 0;
	background-position: left -30px bottom;
	background-repeat: no-repeat;
	background-size: 100%;
}

.audioComponent {
    position: absolute;
    top: 7px;
    left: 161px;
}

.cmp-audioComponent{
    position: relative;
}

.cmp-audioComponent__button{
	padding: 0 0 0 50px;
    line-height: 41px;
    height: 41px;
    color: #1A281A;
    font-family: "Roboto Condensed";
    font-size: 16px;
    font-style: normal;
    font-weight: 500;
    display: flex;
    cursor: pointer;
    background: transparent;
}

.cmp-audioComponent .cmp-audioComponent__button:before {
    content:'';
    position: absolute;
    top: 0;
    left: 0;
	width: 41px;
    height: 41px;
    background: url('/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/desktop/sound-off.png') no-repeat;
    background-size: 100%;
}

.cmp-audioComponent.audio-loading .cmp-audioComponent__button:before {
    background: url('/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/desktop/sound-off.png') no-repeat;
    background-size: 100%;    
}

.cmp-audioComponent.audio-ended .cmp-audioComponent__button:before {
    background: url('/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/desktop/sound-off.png') no-repeat;
    background-size: 100%;
}

.cmp-audioComponent.audio-playing .cmp-audioComponent__button:before {
    background: url('/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/desktop/sound-on.png') no-repeat;
    background-size: 100%;
}

.cmp-audioComponent.audio-paused .cmp-audioComponent__button:before {
    background: url('/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/desktop/sound-off.png') no-repeat;
    background-size: 100%;
}

.cmp-audioComponent__button:focus {    
    /*outline: none;
    border: none;*/
}

.cmp-audioComponent__button span{
    background-image: linear-gradient(#F0AB00 0 0);
    background-position: left bottom 10px;
    background-size: 0% 3px;
    background-repeat: no-repeat;
    transition: background-size 0s;
}

.cmp-audioComponent__button:hover span {    
    background-size: 100% 3px;
	/*text-decoration: underline;
    text-decoration-color: #F0AB00;
    text-decoration-thickness: 3px;*/
}

#systemic-therapies {
    position: absolute;
    font-size: 0;
    top: -120px;
    left: 0;
    display: inline-block;
    width: 100%;
}


@media only screen and (max-width: 991px) {
	.desktop-only {
		display: none;
	}

	.mobile-only {
		display: block;
	}
	
	.tree-bg-wrap {
        display: none;
    }

	.cmp-experiencefragment--header {
		padding: 0;
		background: none;
	}
	
	#if-bcg-fails {
        top: -70px;
    }

    #systemic-therapies {
        top: -70px;
    }
    
	#header-wrapper {
		background: rgba(255, 255, 255, 0.50);
		backdrop-filter: blur(12px);
		top: 0px;
		/* height: 37px; */
		height: 48px;
		display: block;
	}

	.logo-wrapper a {
		padding: 12px 0 0 18px;
		display: inline-block;
	}
	
	.audioComponent {
        left: 160px;
    }

	.logo-wrapper a img {
		width: 99px;
        height: 24px;
	}

	#container-I:after {
		content: none;
	}

	#container-I {
		/* background: url(/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/mobile/header-bg-mob.jpg); */
		background-image: url(/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/mobile/header-bg-mob-new.png);
		background-repeat: no-repeat;
		background-size: contain;
		position: relative;
		background-position: left top;
	}

	#banner-wrap {
		justify-content: center;
		padding: 0 0 13.5% 0;
	}

	#banner-wrap .banner-wrapper {
		width: 100%;
        max-width: 350px;
		display: flex;
		flex-wrap: wrap;
		justify-content: center;
	}

	.yellow-bar {
		max-width: 341px;
		width: 100%;
		height: 35px;
		font-size: 10px;
		line-height: 12px;
		letter-spacing: 0.3px;
		padding: 4px 0 0 7px;
		margin: 0;
	}

	.banner-wrapper h1 {
		font-size: 35px;
		line-height: 53px;
		/* 150.82% */
		letter-spacing: 0.352px;
		margin: 0;
	}

	.banner-wrapper h1 span {
        text-shadow: 2px 2px 20px #000;
        font-size: 0.655em;
        line-height: 30px;
        bottom: -20px;
        letter-spacing: -0.1px;
        word-spacing: 0;
	}
	
	.factors-graphics {
    	display: block;
    }
	
	.factors-graphics img{
		padding: 0;
        max-width: 325px;
	}
	#container-I-wrap {
		padding: 295px 0 0 0;
		padding: 75.564% 0 0 0;
	}

	#banner-wrap:before {
		font-size: 31px;
		line-height: 31px;
		/* 100% */
		left: 103px;
		top: -88px;
	}

	#white-box {
		margin: 0 auto;
		padding: 30px 13px 0 13px;
		height: auto;
		background: rgba(248, 248, 248, 0.90);
		background: rgba(248, 248, 248, 1);
		backdrop-filter: blur(12px);
	}

	#white-box .h2 {
		font-size: 24px;
		line-height: 32px;
		margin: 0 12px 20px 12px;
		background-size: 9.5% 3px;
	}

	#white-box .p1 {
		font-size: 22px;
		line-height: 30px;
		text-align: left;
		margin: 0 12px;
	}

	#white-box .h3 {
		padding: 0;
		font-size: 22px;
		line-height: 28px;
		letter-spacing: -0.44px;
		text-align: left;
		margin: 20px 12px 20px 12px;
	}

    .rect-wrap {
        flex-wrap: wrap;
        gap: 20px;
        padding: 16px 0 17px 0;
        margin: 32px auto 0 auto;
        flex-direction: column;
        max-width: 349px;
        align-items: center;
	}

	.rect-wrap .rect-left,
	.rect-wrap .rect-right {
		padding: 43px 0 21px 25px;
		width: 325px;
	}

	.rect-wrap .rect-right {
		padding: 43px 0 37px 25px;
	}

	.rect-wrap .para-type-1 {
		padding: 0 33px 0 0;
	}

	#after-bcg-fails {
		padding: 30px 0 0 0;
		background-image: url('/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/desktop/crack-left.png');
		background-position: left bottom -60px;
		background-size: 49%;
		background-repeat: no-repeat;
		margin: 0;
	}

	.after-bcg-fails .h2 {
		font-size: 24px;
		line-height: 30px;
		background-size: 8% 3px;
		margin: 0 0 20px 0;
		padding: 0 40px;
	}

	.after-bcg-fails .h2 span {
		padding: 0;
	}

	#after-bcg-wrap {
		padding: 0 25px;
	}

	.after-bcg-fails .p1 {
		margin: 0 0 25px 0;
		font-size: 22px;
		line-height: 30px;
		/* 136.364% */
	}

	.recommend-flex {
		flex-wrap: wrap;
		gap: 28px;
		flex-direction: column;
	}

	.recommend-flex>div {
		padding: 0 50px;
		gap: 12px;
	}

	.recommend-flex>div span {
		font-size: 22px;
		line-height: 26px;
		/* 118.182% */
		letter-spacing: 0.22px;
        max-width: 140px;
	}

	#after-bcg-fails:before {
		background-position: right top;
		background-size: 50%;
	}

	.after-bcg-fails .p2 {
		padding: 0;
		font-size: 14px;
		line-height: 20px;
		margin: 0 0 23px 0;
	}

	.recommend-box {
        margin: 0 auto 24px auto;
        max-width: 325px;
	}

	.recommend-box .recommend-title {
		padding: 0 50px;
	}

	.after-bcg-fails .h3 {
		font-size: 22px;
		line-height: 30px;
		margin: 0 0 16px 0;
	}

	.after-bcg-fails .p3 {
	    font-size: 16px;
		line-height: 22px;
		margin: 0 0 20px 0;
		padding: 0 9px 0 0;
        letter-spacing: 0.16px;
	}

	.after-bcg-fails .p3 span {
		font-size: 18px;
		letter-spacing: 0.18px;
		line-height: 22px;
	}

	.box-3-col {
		flex-direction: column;
		gap: 20px;
		align-content: center;
		flex-wrap: wrap;
	}

	.box-3-col>div span {
		font-size: 18px;
	}

	.box-3-col>div {
		gap: 16px;
		align-items: center;
		backdrop-filter: none;
	}

	.box-3-col .effects,
	.box-3-col .emotional,
	.box-3-col .function {
		padding: 17px 10px 15px 25px;
	}

	#after-bcg-fails:after {
		content: none;
	}

	#local-systemic-therapies:after {
		height: 145px;
		width: 100%;
		background-image: url('/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/mobile/bottom-bg-tree.png');
		background-size: 100% 145px;
	}

	.local-systemic-therapies .h2 {
		font-size: 24px;
		line-height: 35px;
		background-size: 10% 3px;
		padding: 0 50px;
        margin: 0 0 30px 0;
	}

	.local-systemic-therapies {
		padding: 0 25px 54px 25px;
	}

	#local-systemic-therapies span {
		padding: 0;
	}

	#local-systemic-therapies {
		padding: 30px 0 0 0;
	}
	#local-systemic-therapies:before{
		background-image: url(/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/mobile/bottom-bg-right.png);
		background-position: right bottom;
		background-repeat: no-repeat;
		background-size: 100%;
		height: 237px;
		width: 146px;
		z-index: 1;
	}
	#local-systemic-therapies:after{
		background-image: url(/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/mobile/bottom-bg-left-new.png);
        background-position: left bottom;
        background-repeat: no-repeat;
        background-size: 100%;
        height: 229px;
        width: 194px;
	}
	#local-therapies .p1 {
		font-size: 22px;
		line-height: 30px;
        padding: 0;
	}

	.yellow-box {
		max-width: 323px;
		height: auto;
		padding: 22px 22px 58px 22px;
		flex-wrap: wrap;
		text-align: center;
		gap: 20px;
		justify-content: center;
        margin: 0 auto;
	}

	.yellow-box-text {
		width: auto;
		font-size: 22px;
		line-height: 30px;
		/* 136.364% */
		letter-spacing: 0.22px;
	}

	.yellow-box-text span {
		font-size: 22px;
		line-height: 30px;
		letter-spacing: 0.22px;
	}

	#footer-wrapper {
		padding: 29px 0 23px 0;
	}

	.footer-reference-sec {
		padding: 0 25px 24px 25px;
		margin: 0;
	}

	#footer-nav-wrap .footer-nav-sec ul {
		flex-direction: column;
	}

	.footer-nav-sec {
		padding: 13px 0 0 0;
	}

	.footer-nav-sec p {
		max-width: 300px;
		margin: 0 auto;
	}

	.footer-nav-sec .copyright-desc {
		padding: 12px 0 14px 0;
	}

	.hamburger-wrapper {
        display: block;
        cursor: pointer;
        background: url(/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/mobile/mobile-menu-new.png) no-repeat;
        background-size: contain;
        position: absolute;
        right: 13px;
        top: 9px;
        z-index: 10;
        width: 48px;
        height: 34px;
	}

	.ic-hamburger.open .hamburger-wrapper {
		width: 26px;
		height: 36.5px;
		cursor: pointer;
		background: url('/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/mobile/menu-close-mobile.png') no-repeat;
		z-index: 11;
		background-size: 100%;
		/* top: 2px; */
		top: 8px;
	}

	#sec-nav.cmp-navigation {
		display: none;
	}

	.navigation-overlay .cmp-navigation {
		display: none;
		position: absolute;
		background: url(/content/dam/intelligentcontent/unbranded/onc-io-threat/us/en/images/mobile/gradient-bg-top-mob.jpg) no-repeat;
		background-position: bottom center;
		z-index: 3;
		background-size: cover;
	}

	.navigation-overlay.show {
		height: 100vh !important;
		background: rgba(0, 0, 0, 0.80);
        top: 12px;
        position: relative;
	}

	#sec-nav.cmp-navigation:has(+ a.ic-hamburger.open) {
		display: block;
	}

	.ic-header #sec-nav.cmp-navigation:has(+ a.ic-hamburger.open) {
		z-index: 3;
		width: 100%;
		background: #E6E6E6;
		top: 9px;
		padding: 30px 0;
	}

	.ic-header #sec-nav.cmp-navigation:has(+ a.ic-hamburger.open) ul.cmp-navigation__group {
		flex-wrap: wrap;
		align-items: center;
		justify-content: center;
		gap: 45px;
        flex-direction: column;
	}

	.ic-header #sec-nav.cmp-navigation:has(+ a.ic-hamburger.open) ul.cmp-navigation__group li.cmp-navigation__item a.cmp-navigation__item-link {
		line-height: normal;
	}

	.ic-header #sec-nav.cmp-navigation:has(+ a.ic-hamburger.open) ul.cmp-navigation__group li.cmp-navigation__item a.cmp-navigation__item-link:after {
		content: '';
		width: 18px;
		height: 11px;
		background: url(/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/mobile/nav-arrow-mobile.png) no-repeat;
		background-size: 100%;
		display: inline-block;
		margin: 0 0 0 8px;
	}
	
	.cmp-audioComponent__button {
        padding: 0 0 0 42px;
        line-height: 32px;
        height: 32px;
    }
    
    .cmp-audioComponent .cmp-audioComponent__button:before {
        width: 32px;
        height: 32px;
    }
    
    .cmp-audioComponent__button span {
        background-position: left bottom 5px;
    }
    
    div#is-bcg-alone-enough {
        /*top: -50px;*/
        top: -45px;
    }
    
}

@media only screen and (min-width: 991.5px) {
    #container-I>.container {
            background-image: linear-gradient(180deg, rgba(0,0,0,0) 80%, rgba(0,0,0,1) 95%);
    }
}

@media only screen and (min-width: 991.5px) and (max-width: 1439px) {
    #local-systemic-therapies:after{
        background-size: 25%;
    }
    
    #local-systemic-therapies:before{
        background-size: 27%;
    }
    
    #local-systemic-therapies {
        background-size: contain;
    }
    
    /*.tree-bg-wrap {
        background-size: 101%;
    }*/
    
    #container-I>.container {
            background-image: linear-gradient(180deg, rgba(0,0,0,0) 80%, rgba(0,0,0,1) 95%);
    }

}


@media only screen and (min-width: 320px) and (max-width: 349px) {
    #after-bcg-fails:before {
        background-position: right top 37%;
        background-size: 50%;
    }
    
    .audioComponent {
        left: 130px;
    }
    
    .banner-wrapper h1 {
        font-size: 29px;
    }
    
    .yellow-bar {
        font-size: 9px;
    }
    
    #white-box .h2 {
        background-size: 5% 4px;
    }
    
    .after-bcg-fails .h2 {
        background-size: 14% 4px;
    }
    
    .local-systemic-therapies .h2 {
        background-size: 15% 4px;
    }
    
    #local-systemic-therapies:before, #local-systemic-therapies:after {
        background-size: 90%;
    }    
    
    
}

@media only screen and (min-width: 349px) and (max-width: 390px) {
    #local-systemic-therapies:before, #local-systemic-therapies:after {
        background-size: 90%;
    }    
    
    
}


@media only screen and (min-width: 350px) and (max-width: 439px) {
    #after-bcg-fails:before {
        background-position: right top 13%;
        background-size: 50%;
    }
}

@media only screen and (min-width: 440px) and (max-width: 508px) {
    #after-bcg-fails:before {
        background-position: right top;
        background-size: 50%;
    }
}

@media only screen and (min-width: 509px) and (max-width: 991px) {
    #after-bcg-fails:before {
        background-position: right top -14%;
        background-size: 50%;
    }
    
    #after-bcg-fails {
        background-position: left bottom 15px;
        background-size: 30%;
    }
}

@media only screen and (min-width: 991.5px) and (max-width: 1300px) {
    #after-bcg-fails:after {
        background-size: 73%;
        bottom: 90px;
        left: -90px;
    }
    
    #header-wrap {
        padding: 0 10px;
    }
}

@media only screen and (min-width: 991.5px) and (max-width: 1200px) {
    #container-I {
    	background-image: url('/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/desktop/body-bg-new-1200.jpg');
    	background-position: left top -18px;
    }
    
    .h2{
        background-size: 20% 4px;
    }
    
    .after-bcg-fails .h2 {
        background-size: 8% 4px;
    }
    
    .local-systemic-therapies .h2 {
        background-size: 15% 4px;
    }
}

@media screen and (min-width: 992px) and (max-width: 1150px) {
    .after-bcg-fails .h2,
    .local-systemic-therapies .h2 {
        width: 95%;
        margin-inline: auto;
        background-size: 6% 4px;
    }
    
    .local-systemic-therapies .h2 {
        background-size: 14% 4px;
    }

    .recommend-box,
    .box-3-col,
    .yellow-box {
        width: 95%;
        margin-inline: auto;
    }
    
}

@media only screen and (min-width: 1500px) and (max-width: 1700px) {
    #container-I {
    	background-image: url('/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/desktop/body-bg-new-1600.jpg');
    	background-position: left top -18px;
    }
}

@media only screen and (min-width: 1701px) and (max-width: 1900px) {
    #container-I {
    	background-image: url('/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/desktop/body-bg-new-1900.jpg');
    	background-position: left top -18px;
    }
}

@media only screen and (min-width: 1901px) {
    #container-I {
    	background-image: url('/content/dam/intelligentcontent/unbranded/early-recurrencen-mibc/us/en/images/desktop/body-bg-new-2200.jpg');
    	background-position: left top -18px;
    }
}

@media only screen and (min-width: 1270px) and (max-width: 1439px) {
    #container-I>.container {
            background-image: linear-gradient(180deg, rgba(0,0,0,0) 80%, rgba(0,0,0,1) 90%);
    }
}